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Synthesis, biological evaluation and molecular docking of novel 5-phenyl-1H-pyrazol derivatives as potential BRAFV600E inhibitors

Jing-Jun Dong,a   Qing-Shan Li,ac   Shu-Fu Wang,a   Cui-Yun Li,a   Xin Zhao,b   Han-Yue Qiu,a   Meng-Yue Zhaoa and   Hai-Liang Zhu*a  
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a
State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China
E-mail: zhuhl@nju.edu.cn;
Fax: +86 25 83592672 ;
Tel: +86 25 83592672
b
Nanjing Institute of Environmental Science, Ministry of Environmental Protection of China, Nanjing 210042, P. R. China
c
School of Medical Engineering, Hefei University of Technology, Hefei 230009, P. R. China
Org. Biomol. Chem., 2013,11, 6328-6337

DOI: 10.1039/C3OB40776D
Received 17 Apr 2013, Accepted 05 Jun 2013
First published online 05 Jul 2013
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