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Synthesis, biological evaluation and molecular docking of novel 5-phenyl-1H-pyrazol derivatives as potential BRAFV600E inhibitors

Jing-Jun Dong,a   Qing-Shan Li,ac   Shu-Fu Wang,a   Cui-Yun Li,a   Xin Zhao,b   Han-Yue Qiu,a   Meng-Yue Zhaoa and   Hai-Liang Zhu*a  
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State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China
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Nanjing Institute of Environmental Science, Ministry of Environmental Protection of China, Nanjing 210042, P. R. China
School of Medical Engineering, Hefei University of Technology, Hefei 230009, P. R. China
Org. Biomol. Chem., 2013,11, 6328-6337

DOI: 10.1039/C3OB40776D
Received 17 Apr 2013, Accepted 05 Jun 2013
First published online 05 Jul 2013
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