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Diverse reactivity in microwave-promoted catalyst-free coupling of substituted anilines with ethyl trifluoropyruvate and biological evaluation

Chen Zhang,*a   Dao-Min Zhuang,b   Jia Li,a   Si-Yuan Chen,a   Xiao-Long Du,a   Jian-Yong Wang,c   Jing-Yun Li,b   Biao Jiangac and   Jian-Hua Yao*a  
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a
CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
E-mail: zhangchen@mail.sioc.ac.cn, yaojh@mail.sioc.ac.cn;
Fax: (+86) 021-6416-6128 ;
Tel: (+86) 021-54925183
b
Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
E-mail: lijy@nic.bmi.ac.cn ;
Tel: (+86) 021-6694-8672
c
Shanghai Advanced Research Institute, Chinese Academy of Sciences, 99 Haike Road, Shanghai 201210, China
Org. Biomol. Chem., 2013,11, 5621-5633

DOI: 10.1039/C3OB40650D
Received 02 Apr 2013, Accepted 18 Jun 2013
First published online 19 Jun 2013
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