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Issue 23, 2013
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Conformational regulation of substituted azepanes through selective monofluorination

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Abstract

Substituted azepanes are common bioactive epitopes with flexible ring structures. The conformational effects of monofluorination in model azepane rings were investigated by 1H NMR spectroscopy and computational modelling. A single fluorine atom, installed diastereoselectively, was found to bias the azepane ring to one major conformation for one diastereomer.

Graphical abstract: Conformational regulation of substituted azepanes through selective monofluorination

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Publication details

The article was received on 22 Feb 2013, accepted on 23 Apr 2013 and first published on 24 Apr 2013


Article type: Communication
DOI: 10.1039/C3OB40391B
Citation: Org. Biomol. Chem., 2013,11, 3781-3785
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    Conformational regulation of substituted azepanes through selective monofluorination

    A. R. Patel, G. Ball, L. Hunter and F. Liu, Org. Biomol. Chem., 2013, 11, 3781
    DOI: 10.1039/C3OB40391B

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