Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 16, 2013
Previous Article Next Article

Facile dimethylarsenic exchange and pyramidal inversion in its cysteine and glutathione adducts

Author affiliations

Abstract

Rapid thiolate exchange of dimethylarsonium, Me2As+, is observed between two different thiolate species in solution. NMR is used to characterize the equilibrium constants for interthiol transfer as well the rapid intra molecular conformational dynamics which leads to the coalescence of diastereotopic methyl resonances. These rapid exchange kinetics have important consequences of arsenic's toxicity and pharmacology.

Graphical abstract: Facile dimethylarsenic exchange and pyramidal inversion in its cysteine and glutathione adducts

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 05 Feb 2013, accepted on 04 Mar 2013 and first published on 05 Mar 2013


Article type: Communication
DOI: 10.1039/C3OB40268A
Citation: Org. Biomol. Chem., 2013,11, 2578-2581
  •   Request permissions

    Facile dimethylarsenic exchange and pyramidal inversion in its cysteine and glutathione adducts

    D. S. Bohle and Y. Gu, Org. Biomol. Chem., 2013, 11, 2578
    DOI: 10.1039/C3OB40268A

Search articles by author