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Issue 16, 2013
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Facile dimethylarsenic exchange and pyramidal inversion in its cysteine and glutathione adducts

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Abstract

Rapid thiolate exchange of dimethylarsonium, Me2As+, is observed between two different thiolate species in solution. NMR is used to characterize the equilibrium constants for interthiol transfer as well the rapid intra molecular conformational dynamics which leads to the coalescence of diastereotopic methyl resonances. These rapid exchange kinetics have important consequences of arsenic's toxicity and pharmacology.

Graphical abstract: Facile dimethylarsenic exchange and pyramidal inversion in its cysteine and glutathione adducts

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Publication details

The article was received on 05 Feb 2013, accepted on 04 Mar 2013 and first published on 05 Mar 2013


Article type: Communication
DOI: 10.1039/C3OB40268A
Citation: Org. Biomol. Chem., 2013,11, 2578-2581
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    Facile dimethylarsenic exchange and pyramidal inversion in its cysteine and glutathione adducts

    D. S. Bohle and Y. Gu, Org. Biomol. Chem., 2013, 11, 2578
    DOI: 10.1039/C3OB40268A

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