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Issue 17, 2013
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The anomeric effect on the basis of natural bond orbital analysis

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Abstract

The anomeric effect has been assigned as being due to hyperconjugation, electrostatic/steric interactions or exchange effects; thus, there is no general consensus about its actual origin. The classical hyperconjugation model, usually investigated using natural bond orbital (NBO) analysis, has been arbitrarily refuted because it would not explain some cases of the preferred equatorial anomer over the axial one in polar solution. In this study, hyperconjugation was shown to be dependent on the medium and NBO analysis explains quite well the estimated amounts of axial and equatorial 2-substituted tetrahydropyrans (substituents = F, OH, NH2 and CN) both in the gas phase and aqueous solution. Overall, there is no reason to abandon the hyperconjugation model as it plays a dominating role of the anomeric effect in some systems, while NBO analysis reproduces the energetic profiles on the basis of both hyperconjugative and Lewis-type contributions.

Graphical abstract: The anomeric effect on the basis of natural bond orbital analysis

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Publication details

The article was received on 28 Jan 2013, accepted on 05 Mar 2013 and first published on 05 Mar 2013


Article type: Paper
DOI: 10.1039/C3OB40187A
Citation: Org. Biomol. Chem., 2013,11, 2885-2890
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    The anomeric effect on the basis of natural bond orbital analysis

    M. P. Freitas, Org. Biomol. Chem., 2013, 11, 2885
    DOI: 10.1039/C3OB40187A

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