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State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, P.R. China
; Fax: +86-21-50806770
; Tel: +86-21-50806770
Org. Biomol. Chem., 2013,11, 2574-2577
24 Jan 2013,
24 Feb 2013
First published online
26 Feb 2013
A novel Pd/Cu catalyzed domino reaction for the synthesis of functionalized pyrrolo[1,2-b]pyridazines from readily accessible (hetero)aryl propargyl alcohols and 1-amino-2-bromopyrroles was developed. This cascade process involves a Sonogashira cross-coupling reaction, an isomerization and an intramolecular condensation.
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Organic & Biomolecular Chemistry
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