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Issue 13, 2013
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Synthesis of libraries of peptidomimetic compounds containing a 2-oxopiperazine unit in the main chain

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Abstract

Peptoid libraries have been shown to be a useful source of protein-binding agents. However, simple linear peptoids lack conformational constraints, which may limit their binding affinity for proteins. Here we report facile chemistry for the assembly of 2-oxopiperazine rings into the main chain of peptoid-like oligomers, thus rigidifying the structure. This modified sub-monomer synthesis is suitable for the creation of high quality combinatorial libraries.

Graphical abstract: Synthesis of libraries of peptidomimetic compounds containing a 2-oxopiperazine unit in the main chain

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Publication details

The article was received on 20 Dec 2012, accepted on 13 Feb 2013 and first published on 14 Feb 2013


Article type: Communication
DOI: 10.1039/C3OB27476D
Citation: Org. Biomol. Chem., 2013,11, 2088-2092
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    Synthesis of libraries of peptidomimetic compounds containing a 2-oxopiperazine unit in the main chain

    S. Suwal and T. Kodadek, Org. Biomol. Chem., 2013, 11, 2088
    DOI: 10.1039/C3OB27476D

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