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Issue 17, 2013
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Racemization of enantiopure secondary alcohols by Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase

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Abstract

Controlled racemization of enantiopure phenyl-ring-containing secondary alcohols is achieved in this study using W110A secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus (W110A TeSADH) and in the presence of the reduced and oxidized forms of its cofactor nicotinamide-adenine dinucleotide. Racemization of both enantiomers of alcohols accepted by W110A TeSADH, not only with low, but also with reasonably high, enantiomeric discrimination is achieved by this method. Furthermore, the high tolerance of TeSADH to organic solvents allows TeSADH-catalyzed racemization to be conducted in media containing up to 50% (v/v) of organic solvents.

Graphical abstract: Racemization of enantiopure secondary alcohols by Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase

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Publication details

The article was received on 10 Nov 2012, accepted on 04 Mar 2013 and first published on 04 Mar 2013


Article type: Paper
DOI: 10.1039/C3OB27415B
Citation: Org. Biomol. Chem., 2013,11, 2911-2915
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    Racemization of enantiopure secondary alcohols by Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase

    M. M. Musa, R. S. Phillips, M. Laivenieks, C. Vieille, M. Takahashi and S. M. Hamdan, Org. Biomol. Chem., 2013, 11, 2911
    DOI: 10.1039/C3OB27415B

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