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Issue 29, 2013
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Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives

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Abstract

3-(4-Chlorophenyl)-4-substituted pyrazole derivatives were synthesised and tested for their in vitro antifungal activity. Some compounds showed very good antifungal activity against four pathogenic strains of fungi. The same compounds exhibited an interesting activity against the tested strain of Mycobacterium tuberculosis H37Rv. The results suggest that 1,3,4-oxadiazoles and 5-pyrazolinones bearing a core pyrazole scaffold may be promising antifungal and antitubercular agents.

Graphical abstract: Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives

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Publication details

The article was received on 26 Nov 2012, accepted on 31 May 2013 and first published on 12 Jun 2013


Article type: Paper
DOI: 10.1039/C3OB27290G
Citation: Org. Biomol. Chem., 2013,11, 4891-4898
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    Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives

    P. Horrocks, M. R. Pickard, H. H. Parekh, S. P. Patel and R. B. Pathak, Org. Biomol. Chem., 2013, 11, 4891
    DOI: 10.1039/C3OB27290G

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