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School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, China
E-mail: fanxh@mail.lzjtu.cn
; Fax: +86 931 493 8755
; Tel: +86 931 493 8755
Org. Biomol. Chem., 2013,11, 2147-2153
DOI:
10.1039/C3OB27128E
Received
31 Oct 2012,
Accepted
16 Jan 2013
First published online
17 Jan 2013
A new method for the synthesis of diverse N-alkylation compounds was developed via an iron-catalyzed etheric Csp3–O cleavage with the C–N bond formation in the reaction of π-activated ethers with various nitrogen-based nucleophiles. In addition, the mechanism of this reaction was investigated.
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Organic & Biomolecular Chemistry
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