AlCl3 promoted Friedel–Crafts acylation between 4-tert-butylbenzoyl chloride and mesitylene was investigated. The donor–acceptor complex was observed as the major species. Kinetic investigation demonstrated that the reaction was first-order on the donor–acceptor complex and zero-order on ArH, suggesting that the donor–acceptor complex was not the true reactive species. However, the acylium ion was almost invisible with a fairly low concentration under live reaction conditions. It was approved as the true reactive species through kinetic data (“kinetic capture”) in the AlCl3 promoted Friedel–Crafts acylation reaction.
Organic & Biomolecular Chemistry
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