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Issue 10, 2013
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An olefin isomerization/asymmetric Pictet–Spengler cascade via sequential catalysis of ruthenium alkylidene and chiral phosphoric acid

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Abstract

Chiral phosphoric acid works together with Hoveyda–Grubbs II catalyst enabling highly efficient synthesis of enantioenriched tetrahydro-β-carboline (up to 95% yield, 90% ee) through an olefin isomerization/Pictet–Spengler cascade reaction via sequential catalysis.

Graphical abstract: An olefin isomerization/asymmetric Pictet–Spengler cascade via sequential catalysis of ruthenium alkylidene and chiral phosphoric acid

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Publication details

The article was received on 11 Nov 2012, accepted on 14 Jan 2013 and first published on 21 Jan 2013


Article type: Communication
DOI: 10.1039/C3OB00072A
Citation: Org. Biomol. Chem., 2013,11, 1602-1605
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    An olefin isomerization/asymmetric Pictet–Spengler cascade via sequential catalysis of ruthenium alkylidene and chiral phosphoric acid

    Q. Cai, X. Liang, S. Wang and S. You, Org. Biomol. Chem., 2013, 11, 1602
    DOI: 10.1039/C3OB00072A

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