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Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China
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; Tel: (+86)-512-65880307
Org. Biomol. Chem., 2013,11, 1933-1937
09 Jan 2013,
30 Jan 2013
First published online
01 Feb 2013
Organocatalyzed asymmetric α-alkylation of aldehydes with 3-hydroxy-3-indolylox-indoles in aqueous media has been developed. The reactions proceeded efficiently in the presence of the MacMillan catalyst to give the desired products in good to excellent yields with moderate diastereoselectivities and excellent enantioselectivities.
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Organic & Biomolecular Chemistry
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