A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen

Chikako Komeda; Atsushi Ikeda; Jun-ichi Kikuchi; Norihiro Ishida-Kitagawa; Hisashi Tatebe; Kazuhiro Shiozaki; Motofusa Akiyama

doi:10.1039/C2OB27199K

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Organic & Biomolecular Chemistry

Issue 16, 2013

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A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen

Chikako Komeda,^a Atsushi Ikeda,*^a Jun-ichi Kikuchi,^a Norihiro Ishida-Kitagawa,^b Hisashi Tatebe,^b Kazuhiro Shiozaki^b and Motofusa Akiyama^a^c

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Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Japan
E-mail: aikeda@ms.naist.jp ;
Fax: +81 743 72 6099 ;
Tel: +81 743 72 6091

Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Japan

Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Japan

Org. Biomol. Chem., 2013,11, 2567-2570

DOI: 10.1039/C2OB27199K
Received 12 Nov 2012, Accepted 19 Dec 2012
First published online 20 Dec 2012

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To circumvent the limitations of polyethylene glycol (PEG) modified carriers, a photo-triggerable liposome was prepared which was modified by cholesterol derivatives via a cleavable vinyl ether linkage so that the PEGylated coating can be efficiently removed by a photoactivated fullerene. After the photocleavage of the PEG moiety, the intracellular uptake of the photo-triggerable liposome improved.

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Chikako Komeda
Atsushi Ikeda
Jun-ichi Kikuchi
Norihiro Ishida-Kitagawa
Hisashi Tatebe
Kazuhiro Shiozaki
Motofusa Akiyama

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A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen

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