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Access to some 7,9-dideoxy analogues of pancratistatin was achieved by combining our previously reported nitroenal/dioxanone annulation (to form ring C) with a hetero-Diels–Alder/aromatization path to build the dihydroisoquinolinone subunit (rings A and B); testing of their antiproliferative activity afforded some clues about the role of aromatic substituents in pancratistatin's pharmacophore.
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Organic & Biomolecular Chemistry
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