A fluorescent clustered RGD-containing ligand encompassing an MMP substrate was designed and successfully used in vivo for the dual-targeting of αVβ3 integrin receptors and MMP-9 extracellular proteases in the tumor region.
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Integrin and matrix metalloprotease dual-targeting with an MMP substrate–RGD conjugate
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a
Département de Chimie Moléculaire, CNRS: UMR 5250, ICMG FR 2607, Grenoble cedex 9, France
E-mail: didier.boturyn@ujf-grenoble.fr
E-mail: didier.boturyn@ujf-grenoble.fr
b
INSERM U823, Grenoble, France
E-mail: jean-luc.coll@ujf-grenoble.fr ;
Fax: +33 4 7654 9413 ;
Tel: +33 4 7654 9553
E-mail: jean-luc.coll@ujf-grenoble.fr ;
Fax: +33 4 7654 9413 ;
Tel: +33 4 7654 9553
c
Université Joseph Fourier – Grenoble I, 570, rue de la chimie, BP53, 38041 Grenoble cedex 9, France
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Fax: +33 4 5652 0803 ;
Tel: +33 4 5652 0832
Fax: +33 4 5652 0803 ;
Tel: +33 4 5652 0832
Org. Biomol. Chem., 2013,11, 448-452
DOI: 10.1039/C2OB26926K
Received 01 Oct 2012, Accepted 14 Nov 2012
First published online 14 Nov 2012
Organic & Biomolecular Chemistry
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