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Issue 5, 2013
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Virus-mimicking nano-constructs as a contrast agent for near infrared photoacoustic imaging

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Abstract

We report the first proof-of-principle demonstration of photoacoustic imaging using a contrast agent composed of a plant virus protein shell, which encapsulates indocyanine green (ICG), the only FDA-approved near infrared chromophore. These nano-constructs can provide higher photoacoustic signals than blood in tissue phantoms, and display superior photostability compared to non-encapsulated ICG. Our preliminary results suggest that the constructs do not elicit an acute immunogenic response in healthy mice.

Graphical abstract: Virus-mimicking nano-constructs as a contrast agent for near infrared photoacoustic imaging

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Publication details

The article was received on 16 Dec 2012, accepted on 04 Jan 2013 and first published on 08 Jan 2013


Article type: Communication
DOI: 10.1039/C3NR34124K
Citation: Nanoscale, 2013,5, 1772-1776
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    Virus-mimicking nano-constructs as a contrast agent for near infrared photoacoustic imaging

    S. Gupta, M. R. Chatni, A. L. N. Rao, V. I. Vullev, L. V. Wang and B. Anvari, Nanoscale, 2013, 5, 1772
    DOI: 10.1039/C3NR34124K

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