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Issue 7, 2013
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Protein fibrillation and nanoparticle interactions: opportunities and challenges

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Abstract

Due to their ultra-small size, nanoparticles (NPs) have distinct properties compared with the bulk form of the same materials. These properties are rapidly revolutionizing many areas of medicine and technology. NPs are recognized as promising and powerful tools to fight against the human brain diseases such as multiple sclerosis or Alzheimer's disease. In this review, after an introductory part on the nature of protein fibrillation and the existing approaches for its investigations, the effects of NPs on the fibrillation process have been considered. More specifically, the role of biophysicochemical properties of NPs, which define their affinity for protein monomers, unfolded monomers, oligomers, critical nuclei, and other prefibrillar states, together with their influence on protein fibrillation kinetics has been described in detail. In addition, current and possible-future strategies for controlling the desired effect of NPs and their corresponding effects on the conformational changes of the proteins, which have significant roles in the fibrillation process, have been presented.

Graphical abstract: Protein fibrillation and nanoparticle interactions: opportunities and challenges

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Publication details

The article was received on 16 Oct 2012, accepted on 22 Jan 2013 and first published on 28 Jan 2013


Article type: Review Article
DOI: 10.1039/C3NR33193H
Citation: Nanoscale, 2013,5, 2570-2588
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    Protein fibrillation and nanoparticle interactions: opportunities and challenges

    M. Mahmoudi, H. R. Kalhor, S. Laurent and I. Lynch, Nanoscale, 2013, 5, 2570
    DOI: 10.1039/C3NR33193H

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