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Issue 20, 2013
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Sulfidation of silver nanowires inside human alveolar epithelial cells: a potential detoxification mechanism

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Abstract

Silver nanowires (AgNWs) are being developed for use in optoelectronics. However before widespread usage, it is crucial to determine their potential effects on human health. It is accepted that Ag nanoparticles (AgNPs) exert toxic effects by releasing Ag+ ions, but much less is known about whether Ag+ reacts with compounds, or any downstream bioactive effects of transformed AgNPs. Analytical high-resolution transmission electron microscopy has been employed to elucidate cellular uptake and reactivity of AgNWs inside human alveolar epithelial type 1-like cells. AgNWs were observed in the cytoplasm and membrane-bound vesicles, and precipitation of Ag2S within the cell occurred after 1 h exposure. Cell viability studies showed no evidence of cytotoxicity and reactive oxygen species were not observed on exposure of cells to AgNWs. We suggest that Ag2S formation acts as a ‘trap’ for free Ag+, significantly limiting short-term toxicological effects – with important consequences for the safety of Ag-nanomaterials to human health.

Graphical abstract: Sulfidation of silver nanowires inside human alveolar epithelial cells: a potential detoxification mechanism

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Publication details

The article was received on 21 Jun 2013, accepted on 12 Aug 2013 and first published on 16 Aug 2013


Article type: Paper
DOI: 10.1039/C3NR03205A
Citation: Nanoscale, 2013,5, 9839-9847
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    Sulfidation of silver nanowires inside human alveolar epithelial cells: a potential detoxification mechanism

    S. Chen, A. E. Goode, S. Sweeney, I. G. Theodorou, A. J. Thorley, P. Ruenraroengsak, Y. Chang, A. Gow, S. Schwander, J. Skepper, J. (. Zhang, M. S. Shaffer, K. F. Chung, T. D. Tetley, M. P. Ryan and A. E. Porter, Nanoscale, 2013, 5, 9839
    DOI: 10.1039/C3NR03205A

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