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Issue 17, 2013
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Gadolinium embedded iron oxide nanoclusters as T1T2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery

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Abstract

This report illustrates a new strategy of designing a T1T2 dual-modal magnetic resonance imaging (MRI)-visible vector for siRNA delivery and MRI. Hydrophobic gadolinium embedded iron oxide (GdIO) nanocrystals are self-assembled into nanoclusters in the water phase with the help of stearic acid modified low molecular weight polyethylenimine (stPEI). The resulting water-dispersible GdIO–stPEI nanoclusters possess good stability, monodispersity with narrow size distribution and competitive T1T2 dual-modal MR imaging properties. The nanocomposite system is capable of binding and delivering siRNA for knockdown of a gene of interest while maintaining its magnetic properties and biocompatibility. This new gadolinium embedded iron oxide nanocluster provides an important platform for safe and efficient gene delivery with non-invasive T1T2 dual-modal MRI monitoring capability.

Graphical abstract: Gadolinium embedded iron oxide nanoclusters as T1–T2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery

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Publication details

The article was received on 29 May 2013, accepted on 19 Jun 2013 and first published on 26 Jun 2013


Article type: Paper
DOI: 10.1039/C3NR02797J
Citation: Nanoscale, 2013,5, 8098-8104
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    Gadolinium embedded iron oxide nanoclusters as T1T2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery

    X. Wang, Z. Zhou, Z. Wang, Y. Xue, Y. Zeng, J. Gao, L. Zhu, X. Zhang, G. Liu and X. Chen, Nanoscale, 2013, 5, 8098
    DOI: 10.1039/C3NR02797J

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