Jump to main content
Jump to site search

Issue 18, 2013
Previous Article Next Article

Nanomagnet-based removal of lead and digoxin from living rats

Author affiliations

Abstract

In a number of clinical conditions such as intoxication, bacteraemia or autoimmune diseases the removal of the disease-causing factor from blood would be the most direct cure. However, physicochemical characteristics of the target compounds limit the applicability of classical filtration and diffusion-based processes. In this work, we present a first in vivo magnetic blood purification rodent animal model and demonstrate its ability to rapidly clear toxins from blood circulation using two model toxins with stable plasma levels (lead (Pb2+) and digoxin). Ultra-strong functionalized metal nanomagnets are employed to eliminate the toxin from whole blood in an extracorporeal circuit. In the present experimental demonstration over 40% of the toxin (i.e. lead or digoxin) was removed within the first 10 minutes and over 75% within 40 minutes. After capturing the target substance, a magnetic trap prevents the toxin-loaded nanoparticles from entering the blood circulation. Elemental analysis and magnetic hysteresis measurements confirm full particle recovery by simple magnetic separation (residual particle concentration below 1 μg mL−1 (detection limit)). We demonstrate that magnetic separation-based blood purification offers rapid blood cleaning from noxious agents, germs or other deleterious materials with relevance to a number of clinical conditions. Based on this new approach, current blood purification technologies can be extended to efficiently remove disease-causing factors, e.g. overdosed drugs, bacteria or cancer cells without being limited by filter cut-offs or column surface saturation.

Graphical abstract: Nanomagnet-based removal of lead and digoxin from living rats

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 13 May 2013, accepted on 08 Jul 2013 and first published on 11 Jul 2013


Article type: Paper
DOI: 10.1039/C3NR02468G
Citation: Nanoscale, 2013,5, 8718-8723
  • Open access: Creative Commons BY license
  •   Request permissions

    Nanomagnet-based removal of lead and digoxin from living rats

    I. K. Herrmann, A. Schlegel, R. Graf, C. M. Schumacher, N. Senn, M. Hasler, S. Gschwind, A. Hirt, D. Günther, P. Clavien, W. J. Stark and B. Beck-Schimmer, Nanoscale, 2013, 5, 8718
    DOI: 10.1039/C3NR02468G

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author