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Issue 19, 2013
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Specific biomolecule corona is associated with ring-shaped organization of silver nanoparticles in cells

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Abstract

We correlate the localization of silver nanoparticles inside cells with respect to the cellular architecture with the molecular information in the vicinity of the particle surface by combining nanoscale 3D cryo-soft X-ray tomography (cryo-SXT) with surface-enhanced Raman scattering (SERS). The interaction of the silver nanoparticle surface with small molecules and biopolymers was monitored by SERS in vitro over time in living cells. The spectra indicate a stable, time-independent surface composition of silver nanoparticles, despite the changing environment in the endosomal structure. Cryo-SXT reveals a characteristic ring-shaped organization of the silver nanoparticles in endosomes of different cell types. The ring-like structures inside the endosomes suggest a strong association among silver particles and with membrane structures. The comparison of the data with those obtained with gold nanoparticles suggests that the interactions between the nanoparticles and with the endosomal component are influenced by the molecular composition of the corona.

Graphical abstract: Specific biomolecule corona is associated with ring-shaped organization of silver nanoparticles in cells

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Publication details

The article was received on 28 Apr 2013, accepted on 17 Jul 2013 and first published on 19 Jul 2013


Article type: Paper
DOI: 10.1039/C3NR02129G
Citation: Nanoscale, 2013,5, 9193-9198
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    Specific biomolecule corona is associated with ring-shaped organization of silver nanoparticles in cells

    D. Drescher, P. Guttmann, T. Büchner, S. Werner, G. Laube, A. Hornemann, B. Tarek, G. Schneider and J. Kneipp, Nanoscale, 2013, 5, 9193
    DOI: 10.1039/C3NR02129G

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