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Issue 10, 2013
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Endowing carbon nanotubes with superparamagnetic properties: applications for cell labeling, MRI cell tracking and magnetic manipulations

Giuseppe Lamanna,a  Antonio Garofalo,b  Gabriela Popa,b  Claire Wilhelm,c  Sylvie Bégin-Colin,*b  Delphine Felder-Flesch,*b  Alberto Bianco,*a  Florence Gazeau*c  and  Cécilia Ménard-Moyon*a 
Author affiliations

* Corresponding authors

a CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunopathologie et Chimie Thérapeutique, UPR 3572, 67000 Strasbourg, France
E-mail: a.bianco@ibmc-cnrs.unistra.fr, c.menard@ibmc-cnrs.unistra.fr
Fax: +33 388 610680
Tel: +33 388 417098

b Institut de Physique et Chimie des Matériaux de Strasbourg IPCMS, UMR CNRS/UdS 7504, 67034 Strasbourg Cedex 2, France
E-mail: delphine.felder@ipcms.unistra.fr, Sylvie.Begin@ipcms.unistra.fr

c CNRS/Université Paris Diderot, PRES Sorbonne-Paris Cité, Laboratoire Matière et Systèmes Complexes (MSC), 75205 Paris cedex 13, France
E-mail: florence.gazeau@univ-paris-diderot.fr

Abstract

Coating of carbon nanotubes (CNTs) with magnetic nanoparticles (NPs) imparts novel magnetic, optical, and thermal properties with potential applications in the biomedical domain. Multi-walled CNTs have been decorated with iron oxide superparamagnetic NPs. Two different approaches have been investigated based on ligand exchange or “click chemistry”. The presence of the NPs on the nanotube surface allows conferring magnetic properties to CNTs. We have evaluated the potential of the NP/CNT hybrids as a contrast agent for magnetic resonance imaging (MRI) and their interactions with cells. The capacity of the hybrids to magnetically monitor and manipulate cells has also been investigated. The NP/CNTs can be manipulated by a remote magnetic field with enhanced contrast in MRI. They are internalized into tumor cells without showing cytotoxicity. The labeled cells can be magnetically manipulated as they display magnetic mobility and are detected at a single cell level through high resolution MRI.

Graphical abstract: Endowing carbon nanotubes with superparamagnetic properties: applications for cell labeling, MRI cell tracking and magnetic manipulations

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Publication details

The article was received on 04 Feb 2013, accepted on 17 Mar 2013 and first published on 20 Mar 2013


Article type: Paper
DOI: 10.1039/C3NR00636K
Citation: Nanoscale, 2013,5, 4412-4421
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    Endowing carbon nanotubes with superparamagnetic properties: applications for cell labeling, MRI cell tracking and magnetic manipulations

    G. Lamanna, A. Garofalo, G. Popa, C. Wilhelm, S. Bégin-Colin, D. Felder-Flesch, A. Bianco, F. Gazeau and C. Ménard-Moyon, Nanoscale, 2013, 5, 4412
    DOI: 10.1039/C3NR00636K

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