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Issue 12, 2013
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Doped semiconductor nanocrystal based fluorescent cellular imaging probes

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Abstract

Doped semiconductor nanocrystals such as Mn doped ZnS, Mn doped ZnSe and Cu doped InZnS, are considered as new classes of fluorescent biological probes with low toxicity. Although the synthesis in high quality of such nanomaterials is now well established, transforming them into functional fluorescent probes remains a challenge. Here we report a fluorescent cellular imaging probe made of high quality doped semiconductor nanocrystals. We have identified two different coating approaches suitable for transforming the as synthesized hydrophobic doped semiconductor nanocrystals into water-soluble functional nanoparticles. Following these approaches we have synthesized TAT-peptide- and folate-functionalized nanoparticles of 10–80 nm hydrodynamic diameter and used them as a fluorescent cell label. The results shows that doped semiconductor nanocrystals can be an attractive alternative for conventional cadmium based quantum dots with low toxicity.

Graphical abstract: Doped semiconductor nanocrystal based fluorescent cellular imaging probes

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Publication details

The article was received on 31 Jan 2013, accepted on 31 Mar 2013 and first published on 09 Apr 2013


Article type: Paper
DOI: 10.1039/C3NR00549F
Citation: Nanoscale, 2013,5, 5506-5513
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    Doped semiconductor nanocrystal based fluorescent cellular imaging probes

    A. R. Maity, S. Palmal, S. Basiruddin, N. S. Karan, S. Sarkar, N. Pradhan and N. R. Jana, Nanoscale, 2013, 5, 5506
    DOI: 10.1039/C3NR00549F

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