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Issue 12, 2013
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Mesoporous silica nanoparticles as antigen carriers and adjuvants for vaccine delivery

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Abstract

Vaccines have been at the forefront of improving human health for over two centuries. The challenges faced in developing effective vaccines flow from complexities associated with the immune system and requirement of an efficient and safe adjuvant to induce a strong adaptive immune response. Development of an efficient vaccine formulation requires careful selection of a potent antigen, efficient adjuvant and route of delivery. Adjuvants are immunological agents that activate the antigen presenting cells (APCs) and elicit a strong immune response. In the past decade, the use of mesoporous silica nanoparticles (MSNs) has gained significant attention as potential delivery vehicles for various biomolecules. In this review, we aim to highlight the potential of MSNs as vaccine delivery vehicles and their ability to act as adjuvants. We have provided an overview on the latest progress on synthesis, adsorption and release kinetics and biocompatibility of MSNs as next generation antigen carriers and adjuvants. A comprehensive summary on the ability of MSNs to deliver antigens and elicit both humoral and cellular immune responses is provided. Finally, we give insight on fundamental challenges and some future prospects of these nanoparticles as adjuvants.

Graphical abstract: Mesoporous silica nanoparticles as antigen carriers and adjuvants for vaccine delivery

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Publication details

The article was received on 21 Jan 2013, accepted on 04 Apr 2013 and first published on 09 Apr 2013


Article type: Review Article
DOI: 10.1039/C3NR00357D
Citation: Nanoscale, 2013,5, 5167-5179
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    Mesoporous silica nanoparticles as antigen carriers and adjuvants for vaccine delivery

    K. T. Mody, A. Popat, D. Mahony, A. S. Cavallaro, C. Yu and N. Mitter, Nanoscale, 2013, 5, 5167
    DOI: 10.1039/C3NR00357D

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