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Modifying mesoporous silica nanoparticles to avoid the metabolic deactivation of 6-mercaptopurine and methotrexate in combinatorial chemotherapy

Wenjing Wang,a   Chenjie Fang,*a   Xiaozhu Wang,a   Yuxi Chen,a   Yaonan Wang,d   Wei Feng,b   Chunhua Yan,b   Ming Zhao*ac and   Shiqi Peng*a  
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Corresponding authors
a
College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China
E-mail: sqpeng@bjmu.edu.cn
b
Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications & PKU-HKU Joint Laboratory on Rare Earth Materials and Bioinorganic Chemistry, Peking University, Beijing 100871, China
c
Faculty of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan
d
Medical Experiment and Test Center, Capital Medical University, Beijing 100069, China
Nanoscale, 2013,5, 6249-6253

DOI: 10.1039/C3NR00227F
Received 13 Jan 2013, Accepted 31 Mar 2013
First published online 03 Apr 2013
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