Issue 11, 2013
From the journal:

Nanoscale

Optical imaging of non-fluorescent nanodiamonds in live cells using transient absorption microscopy†

Tao Chen,‡a   Feng Lu,‡b   Aaron M. Streets,a   Peng Fei,a   Junmin Quanb  and  Yanyi Huang*a  

* Corresponding authors

a Biodynamic Optical Imaging Center (BIOPIC), College of Engineering, Peking University, Beijing, China
E-mail: yanyi@pku.edu.cn
Fax: +86-010-62758323
Tel: +86-010-62744058

b School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China

Abstract

We directly observe non-fluorescent nanodiamonds in living cells using transient absorption microscopy. This label-free technology provides a novel modality to study the dynamic behavior of nanodiamonds inside the cells with intrinsic three-dimensional imaging capability. We apply this method to capture the cellular uptake of nanodiamonds under various conditions, confirming the endocytosis mechanism.

Graphical abstract: Optical imaging of non-fluorescent nanodiamonds in live cells using transient absorption microscopy

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Article information

DOI
https://doi.org/10.1039/C3NR00308F
Article type
Communication
Submitted
17 Jan 2013
Accepted
04 Apr 2013
First published
10 Apr 2013

Nanoscale, 2013,5, 4701-4705

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Optical imaging of non-fluorescent nanodiamonds in live cells using transient absorption microscopy

T. Chen, F. Lu, A. M. Streets, P. Fei, J. Quan and Y. Huang, Nanoscale, 2013, 5, 4701 DOI: 10.1039/C3NR00308F

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