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Issue 5, 2013
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Perspectives on natural product epigenetic modulators in chemical biology and medicine

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Abstract

Covering: up to the end of 2012

Epigenetic processes are complex regulatory transcriptional pathways that underpin fundamental physiology and are implicated in the aetiology of many diseases. Small molecule modulators of key epigenetic targets will be central in the study of these intricate networks as well as providing highly useful start points for drug discovery efforts. In this review we will give our perspective on the current status of natural product epigenetic modulators, highlighting the limitations, challenges and opportunities for currently identified molecules, as well as potential strategies for novel compound discovery moving forward.

Graphical abstract: Perspectives on natural product epigenetic modulators in chemical biology and medicine

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Publication details

The article was received on 27 Sep 2012 and first published on 11 Feb 2013


Article type: Review Article
DOI: 10.1039/C3NP20097C
Citation: Nat. Prod. Rep., 2013,30, 605-624
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    Perspectives on natural product epigenetic modulators in chemical biology and medicine

    F. L. Cherblanc, R. W. M. Davidson, P. Di Fruscia, N. Srimongkolpithak and M. J. Fuchter, Nat. Prod. Rep., 2013, 30, 605
    DOI: 10.1039/C3NP20097C

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