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Issue 12, 2013
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Impact of copper-catalyzed cross-coupling reactions in natural product synthesis: the emergence of new retrosynthetic paradigms

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Abstract

Covering: up to the end of June 2013

Copper-catalyzed Ullmann–Goldberg-type cross-coupling reactions have undergone nothing short of a renaissance over the last decade and an impressive number of procedures are now available for the formation of C–N, C–O and C–S bonds with remarkable efficiencies and surgical precision. These reactions have been recently integrated into natural product synthesis, which clearly resulted in the emergence of new retrosynthetic paradigms and bond disconnections. The impact of copper-catalyzed cross-coupling reactions in natural product synthesis will be overviewed in this article with an emphasis on the evolution of strategies due to copper catalysis, mostly by comparison with alternative tactics and their relative efficiencies.

Graphical abstract: Impact of copper-catalyzed cross-coupling reactions in natural product synthesis: the emergence of new retrosynthetic paradigms

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Publication details

The article was received on 28 Jul 2013 and first published on 24 Oct 2013


Article type: Review Article
DOI: 10.1039/C3NP70071B
Citation: Nat. Prod. Rep., 2013,30, 1467-1489
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    Impact of copper-catalyzed cross-coupling reactions in natural product synthesis: the emergence of new retrosynthetic paradigms

    G. Evano, C. Theunissen and A. Pradal, Nat. Prod. Rep., 2013, 30, 1467
    DOI: 10.1039/C3NP70071B

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