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Review Article

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

Paul G. Arnison,a   Mervyn J. Bibb,b   Gabriele Bierbaum,c   Albert A. Bowers,d   Tim S. Bugni,e   Grzegorz Bulaj,f   Julio A. Camarero,g   Dominic J. Campopiano,h   Gregory L. Challis,i   Jon Clardy,j   Paul D. Cotter,k   David J. Craik,l   Michael Dawson,m   Elke Dittmann,n   Stefano Donadio,o   Pieter C. Dorrestein,p   Karl-Dieter Entian,q   Michael A. Fischbach,r   John S. Garavelli,s   Ulf Göransson,t   Christian W. Gruber,u   Daniel H. Haft,v   Thomas K. Hemscheidt,w   Christian Hertweck,x   Colin Hill,y   Alexander R. Horswill,z   Marcel Jaspars,aa   Wendy L. Kelly,ab   Judith P. Klinman,ac   Oscar P. Kuipers,ad   A. James Link,ae   Wen Liu,af   Mohamed A. Marahiel,ag   Douglas A. Mitchell,ah   Gert N. Moll,ai   Bradley S. Moore,aj   Rolf Müller,ak   Satish K. Nair,al   Ingolf F. Nes,am   Gillian E. Norris,an   Baldomero M. Olivera,ao   Hiroyasu Onaka,ap   Mark L. Patchett,aq   Joern Piel,aras   Martin J. T. Reaney,at   Sylvie Rebuffat,au   R. Paul Ross,av   Hans-Georg Sahl,aw   Eric W. Schmidt,ax   Michael E. Selsted,ay   Konstantin Severinov,az   Ben Shen,ba   Kaarina Sivonen,bb   Leif Smith,bc   Torsten Stein,bd   Roderich D. Süssmuth,be   John R. Tagg,bf   Gong-Li Tang,bg   Andrew W. Truman,bh   John C. Vederas,bi   Christopher T. Walsh,bj   Jonathan D. Walton,bk   Silke C. Wenzel,bl   Joanne M. Willeybm and   Wilfred A. van der Donk*bn  
*
Corresponding authors
a
Prairie Plant Systems Inc, Botanical Alternatives Inc, Suite 176, 8B-3110 8th Street E, Saskatoon, Canada
b
Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK
c
Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany
d
Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy University of North Carolina, Chapel Hill, USA
e
Pharmaceutical Sciences Division, University of Wisconsin-Madison, Wisconsin, USA
f
Department of Medicinal Chemistry, University of Utah, Salt Lake City, USA
g
Department of Pharmacology and Pharmaceutical Sciences & Department of Chemistry, University of Southern California, 1985 Zonal Avenue, Los Angeles, USA
h
School of Chemistry, EaStCHEM, University of Edinburgh, West Mains Road, Edinburgh, UK
i
Department of Chemistry, University of Warwick, Coventry, United Kingdom
j
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, USA
k
Teagasc Food Research Centre, Moorepark, Fermoy, Co. and Alimentary Pharmabiotic Centre, Cork, Ireland
l
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia
m
Novacta Biosystems Ltd, UH Innovation Centre, College Lane, Hatfield, United Kingdom
n
University of Potsdam, Institute for Biochemistry and Biology, Karl-Liebknecht-Str. 24/25, 14476 Potsdam-Golm, Germany
o
NAICONS Scrl, Via G. Fantoli 16/15, 20138 Milan, Italy
p
Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, USA
q
Institute Molecular Biosciences, Excellence Cluster: Macromolecular Complexes, Goethe University Frankfurt, Max-von-Laue Str. 9, 60438 Frankfurt/M., Germany
r
Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California, San Francisco, USA
s
Center for Bioinformatics & Computational Biology, Delaware Biotechnology Institute, University of Delaware, 15 Innovation Way, Suite 205, Newark, USA
t
Division of Pharmacognosy, Dept Medicinal Chemistry, Uppsala University, BMC Box 574, SE 75123 Uppsala, Sweden
u
Medical University of Vienna, Center for Physiology and Pharmacology, Schwarzspanierstr.17, A-1090 Vienna, Austria
v
J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, USA
w
Department of Chemistry, University of Hawai'i at Manoa, 2545 McCarthy Mall, Honolulu, USA
x
Leibniz Institute for Natural Product Research and Infection Biology (HKI), Beutenbergstr. 11a, 07745 Jena, Germany
y
Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Ireland
z
Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, USA
aa
Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, Scotland, UK
ab
School of Chemistry and Biochemistry and the Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, USA
ac
Department of Chemistry, Department of Molecular and Cell Biology, University of California, Berkeley, USA
ad
Molecular Genetics, University of Groningen, Nijenborgh 7, Groningen, The Netherlands
ae
Department of Chemical and Biological Engineering, A207 Engineering Quadrangle, Princeton University, Princeton, USA
af
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
ag
Fachbereich Chemie/Biochemie der Philipps Universität Marburg, Hans-Meerwein-Str., D-35032 Marburg, Germany
ah
Departments of Chemistry and Microbiology and the Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, USA
ai
Lanthiopharma, Nijenborgh 4, 9747 AG Groningen, The Netherlands
aj
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, 9500 Gilman Drive, La Jolla, USA
ak
Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infectious Research (HZI), Department Microbial Natural Products, Saarland University, Campus C2 3, 66123 Saarbrücken, Germany
al
Department of Biochemistry, Center for Biophysics and Computational Biology, University of Illinois, 600 S. Mathews Ave, Urbana, USA
am
Laboratory of Microbial Gene Technology Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Biotechnology Building, N1432 Aas, Norway
an
Institute of Molecular BioSciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
ao
Department of Biology, University of Utah, Salt Lake City, USA
ap
Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan
aq
Institute of Molecular BioSciences, Massey University, Private Bag 11222, Palmerston North, New Zealand
ar
Kekulé Institute of Organic Chemistry and Biochemistry, University of Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany
as
Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Wolfgang-Pauli-Str. 10, 8093 Zurich, Switzerland
at
Department of Plant Sciences, University of Saskatchewan, Saskatoon, Canada
au
Laboratory of Communication Molecules and Adaptation of Microorganisms, Muséum National d’Histoire Naturelle, Paris, France
av
Teagasc Food Research Centre, Moorepark, Fermoy, Co., and Alimentary Pharmabiotic Centre, Cork, Ireland
aw
University of Bonn, Institute for Medical Microbiology, Immunology and Parasitology, Pharmaceutical Microbiology Section, Meckenheimer Allee 168, D-53115 Bonn, Germany
ax
Department of Medicinal Chemistry and Department of Biology, University of Utah, Salt Lake City, USA
ay
Department of Pathology, Keck School of Medicine of USC, 2011 Zonal Ave., HMR 204, Los Angeles, USA
az
Waksman Institute, Department of Genetics, Rutgers University, Piscataway, USA
ba
Departments of Chemistry and Molecular Therapeutics, The Natural Products Library Initiative at the Scripps Research Institute, The Scripps Research Institute, 130 Scripps Way, #3A1, Jupiter, USA
bb
Department of Applied Chemistry and Microbiology, University of Helsinki, P.O. Box 56, Viikki Biocenter, 00014 Helsinki, Finland
bc
Department of Biological Sciences, Texas A&M University, College Station, TX 77843, USA
bd
Institute of Molecular Biotechnology, Department of Chemistry, University of Aalen, 73430 Aalen, Germany
be
Technische Universität Berlin, Fakultät II—Institut für Chemie, Strasse des 17. Juni 124, 10623 Berlin, Germany
bf
BLIS Technologies Limited Level 1, Centre for Innovation, 87 St David Street, PO Box 56, Dunedin 9054, New Zealand
bg
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
bh
Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
bi
Department of Chemistry, University of Alberta, Edmonton, Canada
bj
Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, USA
bk
Department of Energy, Plant Research Laboratory, Michigan State University, East Lansing, USA
bl
Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infectious Research (HZI), Department Microbial Natural Products, Saarland University, , Campus C2 3, 66123 Saarbrücken, Germany
bm
Department of Biology and Science Education, Hofstra University-North Shore/LIJ, School of Medicine, Hempstead, New York 11549, USA
bn
Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana–Champaign, 600 S. Mathews Avenue, Urbana, USA
Nat. Prod. Rep., 2013,30, 108-160

DOI: 10.1039/C2NP20085F
Received 08 Aug 2012, First published online 19 Nov 2012
This article is part of themed collection: Celebrating the 2014 RSC Prize and Award Winners
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