Issue 11, 2013

The metallacrowns as templates for spontaneous self-assembly of polypeptides into a tetrahelical bundle

Abstract

Amphiphilic peptide sequences with β-aminohydroxamic acid (βahx) at their C-termini were complexed with Cu2+ ions resulting in formation of stable metallacrowns composed of βahx and copper. The ESI-MS data for the obtained compounds show formation of supramolecular structures of MW approx. 7000 Da with the compositions corresponding to metallacrowns. The addition of Cu2+ to a solution of βahx-containing peptides results in distinct changes in the CD spectra indicating a shift of their conformational equilibria toward helical structures. The experiments with enzymatic hydrolysis show that formation of metallacrown systems significantly increases the proteolytic stability of investigated peptides.

Graphical abstract: The metallacrowns as templates for spontaneous self-assembly of polypeptides into a tetrahelical bundle

Supplementary files

Article information

Article type
Paper
Submitted
14 Jun 2013
Accepted
27 Aug 2013
First published
29 Aug 2013
This article is Open Access
Creative Commons BY-NC license

New J. Chem., 2013,37, 3770-3777

The metallacrowns as templates for spontaneous self-assembly of polypeptides into a tetrahelical bundle

M. Cal, Ł. Jaremko, M. Jaremko and P. Stefanowicz, New J. Chem., 2013, 37, 3770 DOI: 10.1039/C3NJ00641G

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