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Issue 10, 2013
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Multifunctional manganese-doped core–shell quantum dots for magnetic resonance and fluorescence imaging of cancer cells

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Abstract

We synthesized cadmium-free CuInS2–Zn1−xMnxS core–shell quantum dots (QDs) for use in dual-mode optical and magnetic resonance (MR) imaging techniques. Manganese content was in the rang of 0.2–2.3% and varies with the amount of Mn2+ content in the reaction. These materials presented a high quantum yield (QY) of 52% in organic solvent. The CuInS2–Zn1−xMnxS nanoparticles were subsequently transferred to the aqueous phase by the aid of cetyltrimethylammonium bromide (CTAB), and the QY values in water reached 18%. Relaxivity measurements showed that these materials had a T1 relaxivity (r1) of 7.2 mM−1 s−1 on the 3.0 T scanner, suggesting the possibility of using the nanoparticles as a T1 contrast agent. The nanomaterials for both optical and MR imaging in aqueous solution were applied to cells in culture. These results showed that the QY and manganese concentration in the nanoparticles was sufficient to produce contrast for both modalities at relatively low concentrations of nanoparticles.

Graphical abstract: Multifunctional manganese-doped core–shell quantum dots for magnetic resonance and fluorescence imaging of cancer cells

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Publication details

The article was received on 19 Apr 2013, accepted on 12 Jul 2013 and first published on 15 Jul 2013


Article type: Paper
DOI: 10.1039/C3NJ00407D
Citation: New J. Chem., 2013,37, 3076-3083
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    Multifunctional manganese-doped core–shell quantum dots for magnetic resonance and fluorescence imaging of cancer cells

    B. Lin, X. Yao, Y. Zhu, J. Shen, X. Yang, H. Jiang and X. Zhang, New J. Chem., 2013, 37, 3076
    DOI: 10.1039/C3NJ00407D

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