Issue 4, 2013

One-pot synthesis of 2,4,5-trisubstituted 1,2,3-triazoles through the cascade reactions of acid chlorides, terminal acetylenes, sodium azide and aryl halides

Abstract

An efficient one-pot reaction of acid chlorides, terminal acetylenes, sodium azide and aryl halides is developed for the regioselective synthesis of 2,4,5-trisubstituted 1,2,3-triazoles. The method is general, convenient, eco-friendly, atom-economical, and could provide excellent yields and regioselectivities.

Graphical abstract: One-pot synthesis of 2,4,5-trisubstituted 1,2,3-triazoles through the cascade reactions of acid chlorides, terminal acetylenes, sodium azide and aryl halides

Supplementary files

Article information

Article type
Paper
Submitted
10 Oct 2012
Accepted
11 Jan 2013
First published
14 Jan 2013

New J. Chem., 2013,37, 965-968

One-pot synthesis of 2,4,5-trisubstituted 1,2,3-triazoles through the cascade reactions of acid chlorides, terminal acetylenes, sodium azide and aryl halides

X. Liu, J. Li and B. Chen, New J. Chem., 2013, 37, 965 DOI: 10.1039/C3NJ40912K

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