Friedel–Crafts hydroxyalkylation through activation of a carbonyl group using AlBr3: an easy access to pyridyl aryl/heteroaryl carbinols

Adhikesavan Harikrishnan; Jayaraman Selvakumar; Elumalai Gnanamani; Suman Bhattacharya; Chinnasamy Ramaraj Ramanathan

doi:10.1039/C2NJ40871F

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Friedel–Crafts hydroxyalkylation through activation of a carbonyl group using AlBr₃: an easy access to pyridyl aryl/heteroaryl carbinols†‡

Adhikesavan Harikrishnan,^a Jayaraman Selvakumar,^a Elumalai Gnanamani,^a Suman Bhattacharya^a and Chinnasamy Ramaraj Ramanathan*^a

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* Corresponding authors

^a Department of Chemistry, Pondicherry University, Puducherry – 605 014, India
E-mail: crrnath.che@pondiuni.edu.in
Fax: +91 413-2656740
Tel: +91 413-2654416

Abstract

Aromatic electrophilic substitution of aromatic/electron rich heteroaromatic compounds with AlBr₃ activated aldehydes/ketone to afford pyridyl aryl/heteroaryl or diaryl carbinols is described. The strong electron donating group dictates the regiochemical outcome of the product.

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Article information

DOI: https://doi.org/10.1039/C2NJ40871F
Article type: Letter
Submitted: 26 Sep 2012
Accepted: 03 Dec 2012
First published: 04 Dec 2012

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New J. Chem., 2013,37, 563-567

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Friedel–Crafts hydroxyalkylation through activation of a carbonyl group using AlBr₃: an easy access to pyridyl aryl/heteroaryl carbinols

A. Harikrishnan, J. Selvakumar, E. Gnanamani, S. Bhattacharya and C. R. Ramanathan, New J. Chem., 2013, 37, 563 DOI: 10.1039/C2NJ40871F

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