Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 3, 2013
Previous Article Next Article

Zinc released from olfactory bulb glomeruli by patterned electrical stimulation of the olfactory nerve

Author affiliations

Abstract

Zinc is a trace element with a multitude of roles in biological systems including structural and cofactor functions for proteins. Although most zinc in the central nervous system (CNS) is protein bound, the CNS contains a pool of mobile zinc housed in synaptic vesicles within a subset of neurons. Such mobile zinc occurs in many brain regions, such as the hippocampus, hypothalamus, and cortex, but the olfactory bulb (OB) contains one of the highest such concentrations in the CNS. Zinc is distributed throughout the OB, with the glomerular and granule cell layers containing the highest levels. Here, we visualize vesicular zinc in the OB using zinc-responsive fluorescent probes developed by one of us. Moreover, we provide the first demonstration that vesicular pools of zinc can be released from olfactory nerve terminals within individual glomeruli by patterned electrical stimulation of the olfactory nerve designed to mimic the breathing cycle in rats. We also provide electrophysiological evidence that elevated extracellular zinc potentiates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated synaptic events. AMPA receptors are required for the synchronous activation of neurons within individual OB glomeruli, and zinc-mediated potentiation leads to enhanced synaptic summation.

Graphical abstract: Zinc released from olfactory bulb glomeruli by patterned electrical stimulation of the olfactory nerve

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 05 Aug 2012, accepted on 29 Jan 2013 and first published on 31 Jan 2013


Article type: Paper
DOI: 10.1039/C3MT20158A
Citation: Metallomics, 2013,5, 208-213
  •   Request permissions

    Zinc released from olfactory bulb glomeruli by patterned electrical stimulation of the olfactory nerve

    L. J. Blakemore, E. Tomat, S. J. Lippard and P. Q. Trombley, Metallomics, 2013, 5, 208
    DOI: 10.1039/C3MT20158A

Search articles by author