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Issue 3, 2013
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Electroanalysis of the interaction between (−)-epigallocatechin-3-gallate (EGCG) and amyloid-β in the presence of copper

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Abstract

The misfolding of amyloid-beta (Aβ) peptide is one of the pathological hallmarks of Alzheimer's disease (AD). Polyphenols are strong antioxidants and metal chelators, with characteristics that are of beneficial therapeutic values for their development as candidates targeting neurodegenerative and metal-induced diseases. We have demonstrated here the electrochemical properties of a green tea component, (−)-epigallocatechin-3-gallate (EGCG), and its potent activity on Aβ peptides. Characterization of early interactions (≤48 h) between EGCG and Aβ was conducted using square wave voltammetry (SWV). The interaction of Cu(II) ions with the Tyr-10 residue of Aβ was shown to be affected by surrounding His residues. Morphological changes due to the binding of EGCG and Cu(II) were also elucidated using transmission electron microscopy (TEM). Electroanalytical techniques are promising for facilitating the investigation of metals and flavonoids in drug screening studies.

Graphical abstract: Electroanalysis of the interaction between (−)-epigallocatechin-3-gallate (EGCG) and amyloid-β in the presence of copper

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Publication details

The article was received on 06 Jun 2012, accepted on 12 Feb 2013 and first published on 13 Feb 2013


Article type: Paper
DOI: 10.1039/C3MT20106F
Citation: Metallomics, 2013,5, 259-264
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    Electroanalysis of the interaction between (−)-epigallocatechin-3-gallate (EGCG) and amyloid-β in the presence of copper

    B. Zhang, X. R. Cheng, I. S. da Silva, V. W. S. Hung, A. J. Veloso, L. Angnes and K. Kerman, Metallomics, 2013, 5, 259
    DOI: 10.1039/C3MT20106F

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