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Issue 3, 2013
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Identification of 4,6-diaryl-1,4-dihydropyridines as a new class of neuroprotective agents

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Abstract

A library of 4,6-diaryl-1,4-dihydropyridines was synthesized using a CAN-catalyzed, Hantzsch-related three component reaction starting from ammonium acetate, β-dicarbonyl compounds and a variety of α,β-unsaturated ketones including chalcones, their vinylogs and heteroanalogues. These compounds lack the structural features needed for vascular activity and were found to prevent calcium overload and behave as neuroprotective agents. One of the compounds, bearing a 2-thienyl substituent at C-4, showed the highest neuroprotective activity and was also a moderate antioxidant, being a good lead compound for further studies in this area.

Graphical abstract: Identification of 4,6-diaryl-1,4-dihydropyridines as a new class of neuroprotective agents

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Publication details

The article was received on 12 Nov 2012, accepted on 23 Jan 2013 and first published on 31 Jan 2013


Article type: Concise Article
DOI: 10.1039/C3MD20345J
Citation: Med. Chem. Commun., 2013,4, 590-594
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    Identification of 4,6-diaryl-1,4-dihydropyridines as a new class of neuroprotective agents

    G. Tenti, J. Egea, M. Villarroya, R. León, J. C. Fernández, J. F. Padín, V. Sridharan, M. xmlns="http://www.rsc.org/schema/rscart38"> <. T. Ramos and J. C. Menéndez, Med. Chem. Commun., 2013, 4, 590
    DOI: 10.1039/C3MD20345J

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