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Issue 7, 2013
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Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

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Abstract

An antibacterial DNA minor groove binder is shown by NOE experiments to self-associate in aqueous solution at temperatures up to 80 °C in an anti-parallel, head-to-tail orientation as found in binding to duplex DNA oligomers.

Graphical abstract: Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

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Publication details

The article was received on 04 Mar 2013, accepted on 17 May 2013 and first published on 20 May 2013


Article type: Concise Article
DOI: 10.1039/C3MD00071K
Citation: Med. Chem. Commun., 2013,4, 1105-1108
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    Exceptionally strong intermolecular association in hydrophobic DNA minor groove binders and their potential therapeutic consequences

    J. A. Parkinson, F. J. Scott, C. J. Suckling and G. Wilson, Med. Chem. Commun., 2013, 4, 1105
    DOI: 10.1039/C3MD00071K

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