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Issue 6, 2013
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Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease

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Abstract

The synthesis of eighteen novel (thia)indanopyrazole derivatives was achieved starting from amino(thia)indanones. Some of them displayed a dual binding site acetylcholinesterase inhibition which makes them potentially interesting for Alzheimer's disease treatment.

Graphical abstract: Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease

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Publication details

The article was received on 07 Feb 2013, accepted on 04 Apr 2013 and first published on 04 Apr 2013


Article type: Concise Article
DOI: 10.1039/C3MD00041A
Citation: Med. Chem. Commun., 2013,4, 925-931
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    Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease

    D. Genest, C. Rochais, C. Lecoutey, J. S. Oliveira Santos, C. Ballandonne, S. Butt-Gueulle, R. Legay, M. Since and P. Dallemagne, Med. Chem. Commun., 2013, 4, 925
    DOI: 10.1039/C3MD00041A

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