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Issue 4, 2013
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Design and synthesis of novel 18F-radiolabelled glucosamine derivatives for cancer imaging

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Abstract

The radiosynthesis of glucosamine and similar analogues would be of great interest due to their role in the biochemical synthesis of glycosylated proteins and lipids. This biochemistry can be exploited for visualisation of cancer cells via molecular imaging. This report details the synthesis of a number of 18F-labelled glucosamine derivatives and evaluation of their tumour uptake and normal tissue distribution in vivo in a mouse model of cancer by positron emission tomography (PET) imaging.

Graphical abstract: Design and synthesis of novel 18F-radiolabelled glucosamine derivatives for cancer imaging

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Publication details

The article was received on 17 Jan 2013, accepted on 29 Jan 2013 and first published on 05 Feb 2013


Article type: Concise Article
DOI: 10.1039/C3MD00023K
Citation: Med. Chem. Commun., 2013,4, 653-656
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    Design and synthesis of novel 18F-radiolabelled glucosamine derivatives for cancer imaging

    L. Carroll, T. H. Witney and E. O. Aboagye, Med. Chem. Commun., 2013, 4, 653
    DOI: 10.1039/C3MD00023K

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