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Issue 1, 2013
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Small molecules aimed at type III secretion systems to inhibit bacterial virulence

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Abstract

The development of new anti-bacterial compounds presents a major challenge to modern medicine as bacterial strains resistant to traditional antibiotics are constantly emerging. Type III secretion systems (T3SSs) are essential for virulence mechanisms of many Gram-negative bacterial pathogens and have therefore emerged as an attractive target for small molecule anti-virulence therapeutics. This has led to several high-throughput screens in search for specific chemicals that inhibit the secretion and translocation of bacterial effector proteins. Several classes of small molecules have now been identified from these screens and this review focuses on their discovery and discusses their potential mechanisms of action and prospects for clinical development.

Graphical abstract: Small molecules aimed at type III secretion systems to inhibit bacterial virulence

  • This article is part of the themed collection: New Talent
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Publication details

The article was received on 27 Jul 2012, accepted on 13 Sep 2012 and first published on 14 Sep 2012


Article type: Review Article
DOI: 10.1039/C2MD20213A
Citation: Med. Chem. Commun., 2013,4, 68-79
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    Small molecules aimed at type III secretion systems to inhibit bacterial virulence

    L. K. Tsou, P. D. Dossa and H. C. Hang, Med. Chem. Commun., 2013, 4, 68
    DOI: 10.1039/C2MD20213A

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