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Issue 11, 2013
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BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells

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Abstract

Dynamic physical interactions between proteins underpin all key cellular processes and are a highly attractive area for the development of research tools and medicines. Proteinprotein interactions frequently involve α-helical structures, but peptides matching the sequences of these structures usually do not fold correctly in isolation. Therefore, much research has focused on the creation of small peptides that adopt stable α-helical structures even in the absence of their intended protein targets. We show that short peptides alkylated with azobenzene crosslinkers can be used to photo-stimulate mitochondrial membrane depolarization and cytochrome c release in permeabilised cells, the initial events of the intrinsic apoptosis pathway.

Graphical abstract: BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells

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Publication details

The article was received on 24 Jun 2013, accepted on 05 Aug 2013 and first published on 13 Aug 2013


Article type: Paper
DOI: 10.1039/C3MB70246D
Citation: Mol. BioSyst., 2013,9, 2597-2603
  • Open access: Creative Commons BY license
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    BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells

    R. J. Mart, R. J. Errington, C. L. Watkins, S. C. Chappell, M. Wiltshire, A. T. Jones, P. J. Smith and R. K. Allemann, Mol. BioSyst., 2013, 9, 2597
    DOI: 10.1039/C3MB70246D

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