Jump to main content
Jump to site search

Issue 11, 2013
Previous Article Next Article

Role of feedback and network architecture in controlling virulence gene expression in Bordetella

Author affiliations

Abstract

Bordetella is a Gram-negative bacterium responsible for causing whooping cough in a broad range of host organisms. For successful infection, Bordetella controls expression of four distinct classes of genes (referred to as class 1, 2, 3, and 4 genes) at distinct times in the infection cycle. This control is executed by a single two-component system, BvgAS. Interestingly, the transmembrane component of the two-component system, BvgS, consists of three phospho-transfer domains leading to phosphorylation of the response regulator, BvgA. Phosphorylated BvgA then controls expression of virulence genes and also controls bvgAS transcription. In this work, we perform simulations to characterize the role of the network architecture in governing gene expression in Bordetella. Our results show that the wild-type network is locally optimal for controlling the timing of expression of the different classes of genes involved in infection. In addition, the interplay between environmental signals and positive feedback aids the bacterium identify precise conditions for and control expression of virulence genes.

Graphical abstract: Role of feedback and network architecture in controlling virulence gene expression in Bordetella

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 05 Jun 2013, accepted on 27 Aug 2013 and first published on 28 Aug 2013


Article type: Paper
DOI: 10.1039/C3MB70213H
Citation: Mol. BioSyst., 2013,9, 2635-2644
  •   Request permissions

    Role of feedback and network architecture in controlling virulence gene expression in Bordetella

    M. K. Prajapat and S. Saini, Mol. BioSyst., 2013, 9, 2635
    DOI: 10.1039/C3MB70213H

Search articles by author