Issue 6, 2013
From the journal:

Molecular BioSystems

Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus†

Xiaoling Wang,a   Jioji Tabudravu,a   Mostafa Ezzat Rateb,ac   Krystal Joan Annand,a   Zhiwei Qin,a   Marcel Jaspars,a   Zixin Deng,b   Yi Yu*b  and  Hai Deng*a  

* Corresponding authors

a Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3LZ, Scotland, UK
E-mail: h.deng@abdn.ac.uk
Tel: +44 (0)1224272953

b Key Laboratory of Combinatory Biosynthesis and Drug Discovery (Ministry of Education), School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan 430071, P. R. China
E-mail: yuyi119@hotmail.com

c Pharmacognosy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt 62111

Abstract

The gene cluster directing actinomycin G biosynthesis in Streptomyces iakyrus has been identified and sequenced. It contains one actinomycin synthetase I (ACMS I) gene and two copies of ACMS II and III genes. Genetic analysis demonstrates a unique partnership between the putative hydroxylation and chlorination activities as both acmG8 and acmG9 genes need to be transcribed for the biosynthesis of actinomycin G2–3, respectively.

Graphical abstract: Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus

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Article information

DOI
https://doi.org/10.1039/C3MB70081J
Article type
Communication
Submitted
25 Feb 2013
Accepted
25 Mar 2013
First published
25 Mar 2013

Mol. BioSyst., 2013,9, 1286-1289

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Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus

X. Wang, J. Tabudravu, M. E. Rateb, K. J. Annand, Z. Qin, M. Jaspars, Z. Deng, Y. Yu and H. Deng, Mol. BioSyst., 2013, 9, 1286 DOI: 10.1039/C3MB70081J

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