Issue 7, 2013
From the journal:

Molecular BioSystems

Human cathelicidin peptide LL37 binds telomeric G-quadruplex†

Jagannath Jana,a   Rajiv Kumar Kar,a   Anirban Ghosh,a   Atanu Biswas,b   Surajit Ghosh,b   Anirban Bhunia*a  and  Subhrangsu Chatterjee*a  

* Corresponding authors

a Biomolecular NMR and Drug Design Laboratory, Department of Biophysics, Bose Institute, P-1/12 CIT Scheme VII M, Kolkata, India
E-mail: bhunia@jcbose.ac.in, subhrangsu@gmail.com
Fax: +91 33-23553886
Tel: +91 33-25693336/340

b Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata, India

Abstract

Stabilization of G-quadruplex inhibits the activity of the enzyme telomerase in cancer cells. We found LL37, a host defense human cathelicidin antimicrobial peptide, to be a potent binder of G-quadruplex structures.

Graphical abstract: Human cathelicidin peptide LL37 binds telomeric G-quadruplex

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Article information

DOI
https://doi.org/10.1039/C3MB70030E
Article type
Communication
Submitted
23 Jan 2013
Accepted
09 Apr 2013
First published
10 Apr 2013

Mol. BioSyst., 2013,9, 1833-1836

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Human cathelicidin peptide LL37 binds telomeric G-quadruplex

J. Jana, R. K. Kar, A. Ghosh, A. Biswas, S. Ghosh, A. Bhunia and S. Chatterjee, Mol. BioSyst., 2013, 9, 1833 DOI: 10.1039/C3MB70030E

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