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Issue 6, 2013
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Application of proteomics technology in adipocyte biology

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Abstract

Obesity and its associated complications have reached epidemic proportions in Western-type societies. Concomitantly, the obesity incidence in developing countries is increasing. One hallmark of obesity is the differentiation of pre-adipocytes into mature triglyceride-loaded adipocytes present in subcutaneous and visceral adipose tissue depots. This may ultimately lead to dysfunctional adipose tissue together with detrimental changes in the profiles of (pre-)adipocyte-secreted proteins, known as adipokines. Obesity-induced alterations in adipokine profiles contribute to the development of obesity-associated disorders. Consequently, the interest in the molecular events responsible for adipose tissue modifications during weight gain and weight loss as well as in the aetiology of obesity-associated disorders is growing. Molecular mechanisms involved in pre-adipocyte differentiation and alterations in adipokine profiles have been examined at the gene and protein level by high-throughput technologies. Independent proteomics studies have contributed significantly to further insight into adipocyte biology, particularly with respect to adipokine profiling. In this review novel findings obtained with adipo-proteomics studies are highlighted and the relevance of proteomics technologies to further understand molecular aspects of adipocyte biology is discussed.

Graphical abstract: Application of proteomics technology in adipocyte biology

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Publication details

The article was received on 21 Dec 2012, accepted on 10 Apr 2013 and first published on 10 Apr 2013


Article type: Review Article
DOI: 10.1039/C3MB25596D
Citation: Mol. BioSyst., 2013,9, 1076-1091
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    Application of proteomics technology in adipocyte biology

    J. Renes and E. Mariman, Mol. BioSyst., 2013, 9, 1076
    DOI: 10.1039/C3MB25596D

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