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Issue 4, 2013
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Optogenetic tools for mammalian systems

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Abstract

Light is fundamental to life on earth. Therefore, nature has evolved a multitude of photoreceptors that sense light across all kingdoms. This natural resource provides synthetic biology with a vast pool of light-sensing components with distinct spectral properties that can be harnessed to engineer novel optogenetic tools. These devices enable control over gene expression, cell morphology and signaling pathways with superior spatiotemporal resolution and are maturing towards elaborate applications in basic research, in the production of biopharmaceuticals and in biomedicine. This article provides a summary of the recent advances in optogenetics that use light for the precise control of biological functions in mammalian cells.

Graphical abstract: Optogenetic tools for mammalian systems

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Publication details

The article was received on 28 Sep 2012, accepted on 30 Jan 2013 and first published on 30 Jan 2013


Article type: Review Article
DOI: 10.1039/C3MB25590E
Citation: Mol. BioSyst., 2013,9, 596-608
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    Optogenetic tools for mammalian systems

    K. Müller and W. Weber, Mol. BioSyst., 2013, 9, 596
    DOI: 10.1039/C3MB25590E

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