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Issue 4, 2013
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Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization

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Abstract

Membrane protein manipulation is a challenging task owing to limited tertiary and quaternary structural stability once the protein has been removed from a lipid bilayer. Such instability can be overcome by embedding membrane proteins in detergent micelles formed from amphiphiles with carefully tuned properties. This study introduces a class of easy-to-synthesize amphiphiles, which are designated CGT (Chae's Glyco-Triton) detergents. Some of the agents are well suited for membrane protein solubilization and stabilization.

Graphical abstract: Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization

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The article was received on 18 Dec 2012, accepted on 23 Jan 2013 and first published on 24 Jan 2013


Article type: Communication
DOI: 10.1039/C3MB25584K
Citation: Mol. BioSyst., 2013,9, 626-629
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    Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization

    P. S. Chae, M. J. Wander, K. H. Cho, P. D. Laible and S. H. Gellman, Mol. BioSyst., 2013, 9, 626
    DOI: 10.1039/C3MB25584K

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