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Issue 3, 2013
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Network motifs provide signatures that characterize metabolism

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Abstract

Motifs are repeating patterns that determine the local properties of networks. In this work, we characterized all 3-node motifs using enzyme commission numbers of the International Union of Biochemistry and Molecular Biology to show that motif abundance is related to biochemical function. Further, we present a comparative analysis of motif distributions in the metabolic networks of 21 species across six kingdoms of life. We found the distribution of motif abundances to be similar between species, but unique across cellular organelles. Finally, we show that motifs are able to capture inter-species differences in metabolic networks and that molecular differences between some biological species are reflected by the distribution of motif abundances in metabolic networks.

Graphical abstract: Network motifs provide signatures that characterize metabolism

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Supplementary files

Publication details

The article was received on 27 Aug 2012, accepted on 18 Dec 2012 and first published on 20 Dec 2012


Article type: Paper
DOI: 10.1039/C2MB25346A
Citation: Mol. BioSyst., 2013,9, 352-360
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    Network motifs provide signatures that characterize metabolism

    E. R. Shellman, C. F. Burant and S. Schnell, Mol. BioSyst., 2013, 9, 352
    DOI: 10.1039/C2MB25346A

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