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Issue 2, 2013
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Quantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes

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Abstract

Type 2 diabetes (T2DM) is a multi-factorial disease with a complex pathogenic mechanism; however a complete understanding of precise biochemical alterations accompanying the onset and progression of T2DM is lacking. Using a combination of untargeted and targeted metabolomic profiling approach we were able to delineate significantly altered metabolites in the diabetic (T2DM) group. Our results indicate significant perturbations in amino acid metabolism, TCA cycle and glycerol-phospholipid metabolism possibly impacting the overall glucose homeostasis in T2DM. A systems approach offers promise towards identification of clinically relevant markers of T2DM and novel molecular targets to foster drug discovery for effective therapeutic development for diabetes.

Graphical abstract: Quantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes

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Publication details

The article was received on 03 Jul 2012, accepted on 22 Nov 2012 and first published on 22 Nov 2012


Article type: Paper
DOI: 10.1039/C2MB25384D
Citation: Mol. BioSyst., 2013,9, 307-317
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    Quantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes

    P. Kaur, N. Rizk, S. Ibrahim, Y. Luo, N. Younes, B. Perry, K. Dennis, M. Zirie, G. Luta and A. K. Cheema, Mol. BioSyst., 2013, 9, 307
    DOI: 10.1039/C2MB25384D

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